Mechanism of Action
PLLA consists of microspheres of a synthetic polymer. The microspheres are less than one micron in diameter and create a reaction that leads to growth of collagen. Studies have shown that after injection into the soft tissue, the microspheres degrade over time into carbon dioxide and water while causing stimulation of type I collagen growth. Imaging studies have shown a threefold increase in skin thickness sustained at 96 weeks. At 9 months PLLA completely disappears and is replaced by collagen. The effects of PLLA treatment have been documented in the Vega, Westminster, Blue Pacific and Apex trials to have lasting results over 24 months. More recent studies have shown the increase in skin thickness to last up to 40 months.
Thank you to Dr. Chris Thiagarajah, our guest blogger today, for sharing his insights and knowledge with us.